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Fildena: A Comprehensive Review

by | Apr 4, 2024 | Uncategorized | 0 comments

Characteristic Details
Active Ingredient Sildenafil Citrate
Available Dosages 25 mg, 50 mg, 100 mg
Formulation Tablets
Prescription Status Prescription Required
More about Fildena

Pharmacokinetics

The pharmacokinetics of Sildenafil are well-characterized. Following oral administration, Fildena achieves peak plasma concentrations within 30 to 120 minutes. Bioavailability is around 40%. Metabolism occurs primarily in the liver via the CYP3A4 and CYP2C9 pathways. The half-life of Sildenafil is approximately four hours. Elimination occurs through both feces and urine. Absorption can be impacted by a high-fat meal, which may delay the time to peak plasma levels.

Sildenafil’s action mechanism involves the inhibition of phosphodiesterase type 5 (PDE5). This inhibition facilitates the increase of cGMP levels, promoting smooth muscle relaxation in the corpus cavernosum and enhancing erectile function. It is important to consider interactions with other medications metabolized by the same liver enzymes. Use with caution in patients with liver impairments.

Dosage Information

Fildena comes in various dosages. Physicians typically start treatment at 50 mg once daily, taken as needed, about one hour prior to sexual activity. Depending on efficacy and tolerability, the dosage may be adjusted. The maximum recommended dosage is 100 mg, while the minimum effective dose is 25 mg. Patients should not exceed one dose in a 24-hour period. Dosage adjustments are necessary for individuals with renal or hepatic impairments.

Administration with or without food is acceptable, although high-fat meals can prolong the onset of action. Patients should adhere to the prescribed dosage and consult healthcare providers if efficacy is not achieved. The dosage may require adjustment based on individual response and tolerability.

Indications

Fildena is primarily indicated for the treatment of erectile dysfunction (ED) in adult males. ED is characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. This condition may result from psychological, neurological, or vascular issues.

By enhancing blood flow to the penis, Fildena facilitates the natural erectile response during sexual stimulation. It is effective across a range of etiologies and severity of ED. Sildenafil has also been indicated for pulmonary arterial hypertension (PAH) under different brand names.

Pregnancy and Breastfeeding

Fildena is not indicated for use in women. Clinical studies have not established safety for pregnant or breastfeeding women. Animal studies have not demonstrated any teratogenic effects, but the absence of clinical trials in this population advises against its use.

In PAH indications, consultation with healthcare professionals is necessary if use during pregnancy is considered. Caution should be exercised, and alternative treatments explored. Breastfeeding mothers are advised to avoid Sildenafil due to unknown effects on infants.

Effects of Fildena

Fildena enhances erectile function by facilitating increased blood flow. This effect is conditional upon sexual stimulation. Common side effects include headache, flushing, and dyspepsia. Rarely, visual disturbances and dizziness may occur.

Adverse reactions such as prolonged erections or priapism require immediate medical intervention. Cardiovascular events are possible in individuals with pre-existing conditions. Interactions with nitrates and alpha-blockers can lead to significant blood pressure drops.

Long-term safety and efficacy have been well-established, yet ongoing monitoring of individual response is advised. For more detailed safety information, refer to the official sources.

Is Non-Prescription Fildena Available?

Non-prescription availability of Fildena does not exist. It is a prescription-only medication. This ensures proper diagnosis and management of erectile dysfunction. Over-the-counter variants might not guarantee efficacy and safety.

Illicit sales of Sildenafil pose significant health risks. These unauthorized products may contain incorrect dosages or harmful ingredients. Patients should seek medications through licensed pharmacies.

  • Always consult healthcare providers for prescriptions.
  • Ensure medications are obtained from reputable sources.
  • Report any adverse effects promptly.

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